Organic Acids
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC Ac-Cys-Pro-Pro-Tyr-Leu-Pro-cyclo(Lys-Tyr-Leu-Cys-Asp)-Leu-Ile-NH2 (disulfide bridge :Cys1-Cys10) | 99.0% | 1672.93 | 10 MG
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2), primarily used in research for schizophrenia and cancer immune regulation.
- Highly selective and potent VIPR2 antagonist.
- Reverses tumor-promoting M2 macrophage phenotype to anti-tumor M1, altering tumor immune microenvironment.
- Inhibits tumor growth.
- Can be formulated as nanoparticles to cross the blood-brain barrier.
- Enhances anti-tumor and neuroprotective activities.
- Prevents VIPR2 over-activation, safeguarding against cognitive impairments and neuronal structural damage in mice.
- Demonstrates anti-tumor activity in murine models, synergistic with anti-PD-1 antibodies.
Medchemexpress LLC Lonodelestat TFA | 906547-89-5 | 99.6% | 1478.73 | 25 MG
Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE). It has potential for research related to cystic fibrosis (CF).
- Potent, orally active, and selective peptide inhibitor of human neutrophil elastase.
- Significantly reduced inflammatory processes of acute lung injury in HNE-treated mice.
- Suitable for research related to cystic fibrosis.
- Soluble in H2O: 20 mg/mL (13.53 mM); requires ultrasonic and warming.
- Powder storage: -80°C for 2 years, -20°C for 1 year.
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture).
Medchemexpress LLC Pamoic acid (Embonic acid) | 130-85-8 | 99.7% | 388.38 | 100 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist that demonstrates neuroprotective and anti-inflammatory properties. Its GPR35 activation may increase the phosphorylation of ERK1/2, which helps to suppress NF-κB-dependent inflammatory genes.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Shows agonist activity at human GPR35 in CHO cell lines.
- Demonstrates neuroprotective activity in a mouse stroke model.
- Reduces infarct size in a GPR35-dependent manner.
- Increases noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain.
- Reduces neutrophil counts.
eMolecules Anilino(phenyl)acetic acid | Combi-Blocks, Inc.MFCD01724775 | 227.263 | C14H13NO2 | 95.000 | OC(=O)C(Nc1ccccc1)c1ccccc1 | 1g | 603152192
Anilino(phenyl)acetic acid | Combi-Blocks, Inc.MFCD01724775 | 227.263 | C14H13NO2 | 95.000 | OC(=O)C(Nc1ccccc1)c1ccccc1 | 1g | 603152192
eMolecules 2968-13-0 | AstaTech | 1-(4-FLUOROPHENYLTHIO)PROPAN-2-ONE | 1g | 273168139 | 73930 | 95 | MFCD00179340 | 184.23 | C9H9FOS
Ambeed | Methyl 5-chloro-22-dimethylpentanoate | 250mg | 682931801 | A765612 | 73441-42-6 | MFCD07782111 | 178.660 | C8H15ClO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC PLP (180-199) TFA | 99.22% | 2085.34 (free base) | 1 MG
PLP (180-199) TFA is the TFA salt form of PLP (180-199). It induces the activation and differentiation of T cells and induces experimental autoimmune encephalomyelitis (EAE) in mouse models.
- Activates and differentiates T cells
- Induces experimental autoimmune encephalomyelitis (EAE) in mouse models
- Molecular weight: 2085.34 (free base)
- Purity: 99.22%
- Sealed storage, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC TP0628103 (TFA) | 2865106-78-9 | 99.6% | 1248.68 | 5 MG
TP0628103 (Compound 18) TFA is a selective inhibitor of MMP-7, with an IC50 value of 0.17 nM. MMP-7 plays an important role in cancer and fibrosis.
- Selective inhibitor of MMP-7
- IC50 value of 0.17 nM
- Plays an important role in cancer and fibrosis research
- For research use only
Apexbio Technology LLC 2X hyperfusion plus master mix (With dye) 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb 2X Hyperfusion plus master mix (With dye) is a ready-to-use 2 premix solution containing polymerase dNTPs an already optimized buffer system and dye Our mix is ideal for any detection and the PCR product can be directly electrophoresed after the amplification without the need to add a loading buffer
Medchemexpress LLC Pamoic acid | 130-85-8 | 99.7% | 388.38 | 50 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties, making it suitable for research into neurological and inflammatory diseases.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Exhibits neuroprotective and anti-inflammatory properties.
- GPR35 activation may increase phosphorylation of ERK1/2, suppressing NF-κB-dependent inflammatory genes.
- Shows neuroprotective activity by activating GPR35, reducing infarct size in mouse stroke models.
- Increases noninflammatory Ly-6CLo monocytes/macrophages and reduces neutrophil counts in the ischemic brain.
Medchemexpress LLC LP17 TFA (LQVTDSGLYRCVIYHPP TFA) | 99.2% | 1961.24 | 5 MG
LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. It substantially alleviates ischemia-induced infarction and neuronal injury by accessing the brain and blocking TREM-1. For research use only.
- Decreases mRNA levels of pro-inflammatory cytokines and chemokines.
- Attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model.
- Interacts with microglial SYK.
- Alleviates ischemia-induced infarction and neuronal injury in mice.
- Reduces infarct volume by 27.3%.
- Reduces TUNEL positive cells and FJC positive neurons.
- Rescues neurological deficits and cognitive dysfunction.
- Inhibits microglial M1 polarization and neutrophil infiltration.
Medchemexpress LLC Tegoprazan | 942195-55-3 | 387.38 | 50 MG
Tegoprazan is a potassium-competitive acid blocker, functioning as a reversible, orally active, and highly selective inhibitor of gastric H+/K+-ATPase. It inhibits gastric acid secretion and motility with in vitro IC50 values ranging from 0.29-0.52 μM. This compound has demonstrated the ability to significantly improve colitis and enhance intestinal epithelial barrier function in mice.
- Reversible, orally active, and highly selective inhibitor of gastric H+/K+-ATPase
- Inhibits gastric acid secretion and motility
- Improves colitis
- Enhances intestinal epithelial barrier function
- Promising for research related to inflammatory bowel disease
- Promising for research related to gastric acid-related diseases
- Promising for research related to motility-impaired diseases